Protein Details: P2X purinoceptor 5

Protein ID

ICDB_Pro_0586

Protein Name

P2X purinoceptor 5

Gene Name

P2rx5

Organism

Rattus norvegicus (Rat)

Length

455 amino acids

AlphaFoldDB

AF-P51578-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel. Permeable to potassium; sodium and calcium (By similarity). Unlike; other P2RX receptors; the P2X5 receptor is also permeable to chloride (By similarity). Acts as an important regulator of inflammatory-related bone loss and osteoclast multinucleation (By similarity).

Sequence

MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLIILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDDDCHAGESVVAGHGLKTGRCLRVGNSTRGTCEIFAWCPVETKSMPTDPLLKDAESFTISIKNFIRFPKFNFSKANVLETDNKHFLKTCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIYIEWDCDLDKAASKCNPHYYFNRLDNKHTHSISSGYNFRFARYYRDPNGVEFRDLMKAYGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKEDANVEVEANEMEQERPEDEPLERVRQDEQSQELAQSGRKQNSNCQVLLEPARFGLRENAIVNVKQSQILHPVKT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 69; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 71; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 189; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 294; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 296; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"; BINDING 314; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:F8W463"

Disease

Location

Predominantly expressed in heart but are also present in brain; spinal cord and adrenal gland

DOI ID

10.1523/jneurosci.16-08-02495.1996; 10.1016/0014-5793(96)00499-1; 10.1038/nature02426; 10.1124/mol.54.6.989; 10.1074/jbc.274.22.15415; 10.1074/jbc.m606113200; 10.1074/jbc.ra119.009959

RefSeq

NP_542958.2